TABLE 6.

Trends in in vitro resistance to voriconazole among Candida spp. as determined by CLSI disk diffusion testing over a 7-year period^a,b

Species	2001-2004		2005		2006		2007
	No. of isolates tested	% R	No. of isolates tested	% R	No. of isolates tested	% R	No. of isolates tested	% R
C. albicans	68,575	1.2	18,630	1.5	18,965	1.0	19,795	1.0
C. glabrata	12,643	10.3	3,185	9.5	3,413	10.2	3,727	9.4
C. tropicalis	8,171	6.1	2,136	4.5	2,317	3.8	2,574	5.1
C. parapsilosis	7,464	1.8	1,581	1.9	1,724	1.3	1,687	1.8
C. krusei	2,765	7.7	684	7.9	742	6.5	814	8.0
C. guilliermondii	872	4.9	184	6.5	155	9.7	164	5.5
C. lusitaniae	655	1.8	163	3.1	195	0.5	202	3.0
C. kefyr	514	0.8	173	2.9	153	0.0	192	0.0
C. inconspicua	274	5.5	77	2.6	89	2.2	123	2.4
C. famata	359	6.4	87	1.1	72	1.4	88	5.7
C. rugosa	446	26.7	33	3.0	38	0.0	63	4.8
C. dubliniensis	111	0.9	57	0.0	70	1.4	70	1.4
C. norvegensis	134	2.2	36	0.0	47	10.4	29	6.9
C. lipolytica	79	17.7	17	0.0	14	14.3	18	11.1
C. sake	20	0.0	13	7.7	27	11.1	27	7.4
C. pelliculosa	47	0.0	14	14.3	19	5.3	6	16.7
C. apicola					44	2.3	13	0.0
C. zeylanoides	48	8.3	7	0.0	2	0.0	10	0.0
C. valida	9	11.1	7	28.6	1	0.0	5	0.0
C. intermedia	10	0.0	8	0.0	3	0.0	4	0.0
C. pulcherrima	6	0.0	2	0.0	4	0.0	2	0.0
C. haemulonii	6	0.0	2	50.0	1	0.0
C. stellatoidea							7	14.3
C. utilis			1	0.0	2	0.0	4	0.0
C. humicola	2	50.0			2	50.0	2	0.0
C. lambica					2	0.0	3	33.3
C. ciferrii					1	0.0	1	0.0
C. colliculosa					1	0.0	1	0.0
C. holmii							1	0.0
C. marina							1	0.0
C. sphaerica							1	0.0
Candida spp.c	6,022	4.7	1,183	4.9	1,031	2.4	1,341	2.0

^aIsolates were obtained from 133 institutions.

^b% R, percent resistant (zone diameter, ≤13 mm).

^cCandida species not otherwise identified.