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. 2010 Feb 17;30(7):2504–2512. doi: 10.1523/JNEUROSCI.3262-09.2010

Figure 5.

Figure 5.

NPFR1 suppresses larval avoidance to capsaicin induced by ectopically expressed mammalian TRPV1. UAS–TRPV1 encodes a variant of the mammalian vanilloid receptor TRPV1 (TRPV1E600K). A, Control larvae expressing UAS–TRPV1 driven by pain–gal4 migrate away from agar paste containing 400 nm capsaicin. B, Experimental larvae expressing both NPFR1 and TRPV1 in PAIN cells mostly remained on the capsaicin medium. C, Quantification of avoidance response of transgenic larvae in media containing capsaicin. p < 0.001. D, Quantification of capsaicin-induced larval aggregation on the sugar-free capsaicin medium. Larvae expressing TRPV1 alone (pain–gal4/UAS–TRPV1) but not those coexpressing TRPV1 and NPFR1 (pain–gal4/UAS–TRPV1/UAS–npfr1cDNA) showed capsaicin-elicited aggregation. p < 0.001.