Table 2.
Renal biopsy findings in patients with collapsing FSGS after treatment with IFN
| Parameter | Patient |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | |
| Light microscopy | |||||||||||
| no. of glomeruli | 7 | 6 | 13 | 33 | 29 | 12 | 21 | 23 | 30 | 11 | 19 |
| no. of GS glomeruli | 1 | 0 | 3 | 1 | 5 | 0 | 4 | 1 | 5 | 1 | 1 |
| no. of SS glomeruli | 1 | 5 | 3 | 6 | 10 | 5 | 7 | 1 | 3 | 5 | 13 |
| TA/IF | Moderate | Moderate | Mild | Mild | Moderate | Moderate | Moderate | Mild | Moderate | Severe | Severe |
| Interstitial inflammation | Mild | Mild | Mild | Mild | Moderate | Moderate | Moderate | Mild | Mild | Moderate | Moderate |
| Tubular injury | Yes | Diffuse | Yes | Yes | Diffuse | Diffuse | Yes | Yes | Yes | Yes | Diffuse |
| Tubular microcysts | No | No | No | No | Yes | Yes | No | No | No | Yes | Yes |
| Vascular disease | No | Mild | No | Mild | Moderate | Moderate | No | Mild | Mild | Moderate | Moderate |
| Electron microscopy | |||||||||||
| % FPE | 80 | 100 | 90 | 80 | 100 | 100 | 70 | 90 | 90 | 75 | 75 |
| TRIs | 2+ | 3+ | 2+ | 2+ | 2+ | 2+ | 3+ | 3+ | 3+ | 2+ | No |
| deposits | Rare mesangial | No | Rare mesangial | No | No | No | No | No | No | No | No |
FPE, foot process effacement; GS, globally sclerotic; SS, segmentally sclerotic; TA/IF, tubular atrophy and interstitial fibrosis; TRIs, endothelial tubuloreticular inclusions.