Table.

Summary of randomised trials comparing colloid and crystalloid fluid resuscitation that met criteria for inclusion

Trial*	Type of injury	No of patients	Treatment		Length of follow up	Mortality reported	Allocation concealment
			Colloid	Crystalloid
Lowe et alw1-w3	Trauma	171	50 g albumin/200 ml Ringer’s lactate	Ringer’s lactate	5 days	Yes	1
Modigw4 w5	Trauma	31	Dextran-70 in Ringer’s acetate	Ringer’s acetate	To definitive reconstructive surgery	Yes	1
Nagy et alw6	Trauma	41	Pentastarch in 0.9% NaCl	Ringer’s lactate	Unspecified	Yes	1
Younes et alw7	Trauma	70	6% dextran-70 in 7.5% NaCl	7.5% NaCl	To discharge	Yes	3
Vassar et alw8	Trauma	174	6% dextran-70 in 7.5% NaCl	7.5% NaCl	To hospital discharge	Yes	3
Vassar et alw9	Trauma	149	6% or 12% dextran-70 in 7.5% NaCl	7.5% NaCl	To hospital discharge	Yes	3
Evans et alw10	Trauma	25	Haemacell in Ringer’s lactate	Ringer’s lactate	Unspecified	No	2
Skillman et alw11	Surgery	16	25% concentrated salt-poor albumin; 1 g/kg and 5% albumin in saline	Ringer’s lactate with 5% dextrose	1 day	No	2
Boutros et alw12	Surgery	24	Albumin in 5% dextrose	5% dextrose in lactated Ringer’s; 5% dextrose in 0.45% NaCl	To 48 hours postoperative	Yes	2
Virgilio et alw13	Surgery	29	5% albumin in Ringer’s lactate	Ringer’s lactate	2½ weeks	Yes	2
Grundmann et alw14 w15	Surgery	20	Human albumin and crystalloid (details not reported)	Crystalloid (details not reported)	Unspecified	Yes	1
Karanko et alw16 w17	Surgery	36	6% dextran-70 in 0.9% NaCl or in 5% glucose	Ringer’s acetate gluconate	2 weeks	Yes	2
Ley et alw18	Surgery	21	6% hetastarch and 5% plasma protein fraction	0.9% NaCl	To discharge	No	2
Prein et alw19	Surgery	18	10% hydroxyethylstarch in 154 mmol/l NaCl and plasma protein solution; 20% human albumin solution	Ringer’s lactate	Unspecified	No	2
Dawidson et alw20	Surgery	20	3% dextran-60 in Ringer’s lactate	Ringer’s lactate	To discharge	Yes	2
Hartmann et alw21	Surgery	29	Dextran-70 in NaCl with 2.5% glucose	NaCl with 2.5% glucose	7 days	No	2
Eleftheriadis et alw22	Surgery	91	6% hydroxyethylstarch	Ringer’s solution and 3.5% gelatine solution	Unspecified	No	2
Tollosfrud et alw23	Surgery	40	Haemacell; dextran-70; albumin 40 mg/ml in saline	Ringer’s acetate	To 48 hours	Yes	3
Wahba et alw24	Surgery	22	Haemacell in Ringer’s lactate	Ringer’s lactate	To discharge	Yes	2
Bocanegra et alw25	Burns	153	Plasma with saline; whole blood supplemented with 5% glucose	Isotonic saline	To 60 hours, then unspecified	Yes	1
Hall et alw26	Burns	172	6% dextran-70 in 0.9% NaCl	Ringer’s lactate	To 5 years	Yes	1
Jelenko et alw27-w30	Burns	12	Albumin in hypertonic saline (240 mEq Na+, 120 mEq Cl−, 120 mEq lactate, 3.5 torr/l colloid)	Hypertonic saline (240 mEq Na+, 120 mEq Cl−, 120 mEq lactate)	To end of resuscitation	Yes	2
Goodwin et alw31	Burns	79	2.5% albumin in Ringer’s lactate	Ringer’s lactate	To discharge	Yes	2
Rackow et alw32-w34	Septic and hypovolaemic shock	26	6% hydroxyethylstarch; 5% albumin	0.9% NaCl	To discharge	Yes	2
Metildi et alw35	Adult respiratory distress syndrome	46	50% albumin salt-poor serum in Ringer’s lactate	Ringer’s lactate	To discharge	Yes	2
Pockaj et alw36	Vascular leak syndrome	107	5% albumin in 154 mEq/l NaCl	0.9% normal saline with 154 mEq/l NaCl	Unspecified	No	2

^*For list of references see longer version of article on our website www.bmj.com.