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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Mech Ageing Dev. 2010 Jan 18;131(2):144–155. doi: 10.1016/j.mad.2010.01.002

Fig. 7.

Fig. 7

Proteasomes from the individual subcellular fraction are characterized by distinctive peptidase specificity expressed as ratio of the ChT-L to T-L and ChT-L to PGPH activity (a). There is an age associated increasing trend of the ChT-L to T-L activity ratio in cytosolic and nuclear fractions (b). The specificity of proteasome can be approximated by ratios between specific activities of the major proteasomal peptidase. Changes in the specificity likely result in shifts of the cleavage rates of distinct substrates and a pattern of generated products.