Table 2.

Genetic variation in PGES, EP2, and EP4 and risk of colorectal adenoma^a

Gene	SNP	Genotypeb	Cases	Controls	OR	95%CI	pc	p-trend
PGES	−1254T>C	TT	435	526	1.00	–
		TC or CC	40	40	1.28	0.79-2.07	0.32	NA
	−664A>T	AA	397	468	1.00	–
		AT or TT	86	114	0.94	0.67-1.30	0.69	NA
	211A>G	AA	313	381	1.00	–
		AG	147	175	1.10	0.83-1.45
		GG	22	21	1.23	0.64-2.36	0.70	0.40
	1152G>A	GG	429	510	1.00	–
		GA or AA	54	72	0.92	0.62-1.36	0.66	NA
	3006G>A	GG	459	546	1.00	–
		GA or AA	24	36	0.86	0.49-1.51	0.60	NA
	13425A>C	AA	435	526	1.00	–
		AC or CC	40	40	1.28	0.79-2.07	0.40	NA
EP2	−1722A>G	AA	171	222	1.00	–
		AG	234	269	1.22	0.92-1.62
		GG	78	89	1.20	0.81-1.77	0.35	0.23
	−967G>A	GG	436	531	1.00	–
		GA or AA	47	51	1.14	0.74-1.78	0.55	NA
	−616G>C	GG	367	444	1.00	–
		GC or CC	116	137	1.01	0.75-1.36	0.96	NA
	1690G>A	GG	448	539	1.00	–
		GA or AA	34	43	1.05	0.64-1.73	0.83	NA
	4950G>A	GG	400	448	1.00	–
		GA or AA	83	134	0.71	0.52-0.99	0.04	NA
	9814C>A	CC	288	349	1.00	–
		CA	159	197	1.00	0.76-1.32
		AA	36	35	1.10	0.66-1.85	0.93	0.80
	12010G>A	GG	342	406	1.00	–
		AG	122	157	0.96	0.72-1.29
		AA	19	19	1.03	0.52-2.05	0.96	0.89
	15674G>A	GG	311	384	1.00	–
		AG	145	177	1.01	0.76-1.33
		AA	27	21	1.41	0.76-2.62	0.55	0.48
EP4	Val294Ile	Val/Val	476	565	1.00	–
		Val/Ile	20	25	0.93	0.49-1.75	0.82	NA
	−1529G>A	GG	186	238	1.00	–
		GA	218	263	0.91	0.69-1.20
		AA	79	79	0.81	0.55-1.19	0.54	0.27
	−1408G>A	GG	251	326	1.00	–
		GA	199	223	0.87	0.66-1.13
		AA	32	31	0.84	0.49-1.45	0.53	0.28
	−1307G>A	GG	169	166	1.00	–
		GA	211	293	1.42	1.06-1.91
		AA	103	123	1.19	0.83-1.70	0.06	0.23
	−132C>G	CC	401	475	1.00	–
		CG or GG	82	106	0.89	0.64-1.24	0.49	NA
	1455A>G	AA	175	225	1.00	–
		AG	203	254	0.90	0.68-1.20
		GG	86	88	0.81	0.56-1.19	0.54	0.27
	2472A>G	AA	137	182	1.00	–
		AG	222	280	0.92	0.68-1.25
		GG	122	120	0.74	0.52-1.06	0.23	0.11
	6374G>A	GG	278	351	1.00	–
		GA	181	199	0.86	0.66-1.13
		AA	24	32	1.13	0.63-2.03	0.46	0.63
	8907G>A	GG	219	278	1.00	–
		GA	206	240	0.90	0.69-1.18
		AA	58	64	0.89	0.58-1.36	0.71	0.45
	11851G>A	GG	379	454	1.00	–
		GA or AA	103	128	1.06	0.78-1.45	0.71	NA
	13877A>C	AA	257	315	1.00	–
		AC	196	223	0.90	0.69-1.18
		CC	29	43	1.22	0.72-2.06	0.49	1.00
	13981A>G	AA	178	195	1.00	–
		AG	220	289	1.27	0.95-1.68
		GG	85	98	1.05	0.72-1.53	0.23	0.50

^aAdjusted for age and sex.

^bThe homozygous variant and heterozygous genotypes are grouped together if <10 cases or <10 controls were of the homozygous variant genotype.

^cLikelihood ratio test of a model containing dummy variables for each SNP + age and sex vs. a model containing only age and sex.