Table 3.

Genetic variation in PGDH and risk of colorectal adenoma^a

SNP	Genotypeb	Cases	Controls	OR	95%CI	pc	p-trend
−1868G>A	GG	359	437	1.00	–
	GA or AA	124	145	1.10	0.82-1.48	0.51	NA
−1635G>A	GG	121	164	1.00	–
	GA	238	288	1.22	0.89-1.66
	AA	122	128	1.31	0.91-1.88	0.30	0.14
343C>A	CC	412	511	1.00	–
	CA or AA	70	71	1.31	0.90-1.91	0.16	NA
Gln52Gln	GG	171	192	1.00	–
	GA	225	283	0.97	0.73-1.29
	AA	84	104	1.00	0.68-1.45	0.98	0.94
782A>G	AA	338	384	1.00	–
	AG	129	187	0.76	0.57-1.01
	GG	15	10	1.51	0.64-3.56	0.09	0.29
1113G>A	GG	374	464	1.00	–
	GA or AA	109	118	1.14	0.84-1.56	0.41	NA
1543G>A	GG	137	155	1.00	–
	GA	214	287	0.78	0.58-1.07
	AA	131	139	0.95	0.67-1.35	0.24	0.73
3580G>A	GG	297	337	1.00	–
	GA	161	220	0.84	0.64-1.10
	AA	25	25	1.15	0.62-.13	0.37	0.53
9442A>G	AA	223	298	1.00	–
	AG	210	217	1.21	0.92-1.58
	GG	50	66	0.95	0.62-1.46	0.32	0.63
9691C>A	CC	247	286	1.00	–
	CA	187	249	0.89	0.68-1.17
	AA	48	47	1.29	0.81-2.05	0.28	0.77
12184A/-	AA	375	427	1.00	–
	A/- or -/-	110	136	0.94	0.69-1.28	0.70	NA
13316A>C	AA	221	255	1.00	–
	AC	208	259	0.95	0.72-1.24
	CC	53	68	0.94	0.61-1.44	0.91	0.69
13796C>T	CC	273	322	1.00	–
	CT	177	217	0.99	0.76-1.30
	TT	33	43	0.90	0.54-1.50	0.92	0.77
16362G>A	GG	282	363	1.00	–
	GA	168	182	1.16	0.88-1.53
	AA	33	36	1.06	0.63-1.78	0.57	0.43
17450A>G	AA	394	445	1.00	–
	AG or GG	88	135	0.79	0.58-1.09	0.15	NA
18349G>A	GG	379	452	1.00	–
	GA or AA	104	129	0.96	0.71-1.31	0.81	NA
19433G>A	GG	243	275	1.00	–
	GA	201	259	0.91	0.70-1.19
	AA	37	48	0.88	0.54-1.44	0.76	0.47
19979A>T	AA	338	378	1.00	–
	AT	135	166	0.96	0.72-1.28
	TT	14	19	0.86	0.40-1.84	0.90	0.67
20518A>G	AA	160	208	1.00	–
	AG	228	267	1.08	0.81-1.44
	GG	95	107	1.12	0.78-1.62	0.79	0.50
23196G>A	AA	262	304	1.00	–
	AG	180	243	0.87	0.67-1.14
	GG	41	33	1.39	0.83-2.34	0.19	0.82
26646G>A	GG	320	381	1.00	–
	GA	141	175	0.98	0.74-1.30
	AA	22	26	1.09	0.58-2.06	0.95	0.94
31659A>G	AA	356	420	1.00	–
	AG	111	144	0.90	0.67-1.22
	GG	14	18	0.92	0.43-1.97	0.79	0.52

^aAdjusted for age and sex.

^bThe homozygous variant and heterozygous genotypes are grouped together if <10 cases or <10 controls were of the homozygous variant genotype.

^cLikelihood ratio test of a model containing dummy variables for each SNP + age and sex vs. a model containing only age and sex.