Table 4.

Genetic variation in PGES, EP4, and PGDH, weekly fish intake, and risk of adenoma^a

		Fish intake
		<1 serving per week				1-2 servings per week				>2 servings per week
Gene	SNP	Cases	Controls	OR	95% CI	Cases	Controls	OR	95% CI	Cases	Controls	OR	95% CI
PGES	−664A>T
	AA	90	106	1.00	–	190	239	1.06	0.72-1.55	113	108	1.31	0.83-2.04
	AT or TT	21	17	1.74	0.81-3.76	47	59	1.01	0.59-1.71	17	36	0.56	0.28-1.13
					global p-interaction=0.02 SNP trendb p-interaction=0.01
EP4	Val294Ile
	Val/Val	110	116	1.00	–	235	288	0.90	0.63-1.27	126	45	0.87	0.58-1.31
	Val/Ile or Ile/Ile	2	8	0.27	0.05-1.41	10	15	0.80	0.32-2.00	8	1	7.75	0.81-78.83
					global p-interaction=0.02 SNP trendb p-interaction=0.01
PGDH	19979A>T
	AA	78	83	1.00	–	156	196	0.95	0.63-1.45	99	90	1.26	0.78-2.05
	AT or TT	30	38	1.06	0.56-2.00	86	87	1.25	0.78-2.03	33	53	0.64	0.35-1.18
					global p-interaction=0.03 SNP trendb p-interaction=0.03
	31659A>G
	AA	76	99	1.00	–	171	209*	1.15	0.77-1.71	105	99	1.35	0.85-2.15
	AG or GG	34	24	1.86	0.96-3.61	65	89	1.04	0.64-1.70	25	45	0.75	0.40-1.44
					global p-interaction=0.03 SNP trendb p-interaction=0.02

^aAdjusted for age, BMI, total intakes of energy, alcohol, and fiber, sex, post-menopausal hormone use (women only), and smoking (pack-years)

^bTest for differences in fish intake trend among strata of genotype