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. Author manuscript; available in PMC: 2010 Apr 5.
Published in final edited form as: Dev Dyn. 2006 Mar;235(3):586–593. doi: 10.1002/dvdy.20688

Figure 3. Bves interaction at the tight junction.

Figure 3

A schematic representation depicts Bves at the intercellular tight junction (TJ) of polarized epithelial cells. The TJ acts as a paracellular diffusion barrier but also functions regulating processes such as proliferation and differentiation. The TJ consists of several integral membrane proteins including occludin and claudins that bind the actin network via peripheral membrane components, such as ZO proteins. It remains possible that, through ZO-1, Bves also interacts with the actin cytoskeleton to maintain TJ integrity. The proteins and protein interactions shown here do not encompass all that exist at the TJ. The adherens junction, desmosome, and gap junction (not shown) lie subadjacent to the TJ within the lateral membrane.