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Effects of abiraterone acetate on adrenal steroid biosynthesis. Inhibition of 17α-hydroxylase and and C17,20-lyase resulted in substantial decreases in circulating androgen levels (dehydroepiandrosterone sulfate [DHEA-S] and testosterone), with increases in upstream mineralocorticoids (deoxycorticosterone and corticosterone). Adrenocorticotropic hormone (ACTH) levels increased in response to decreases in circulating cortisol levels. LLQ, lower limit of quantitation.
