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The cAMP-PDE distribution in cumulus cells and oocytes. Cyclic AMP-PDE activity was measured in COCs (A), denuded oocytes (B), and cumulus cells (C). The results are presented as total cAMP-PDE activity and as cAMP-PDE activity inhibited by IBMX at 1 mM, inhibited by cilostamide at 10 μM, and inhibited by rolipram at 10 μM. The data presented are the mean ± SEM of at least four replicates.
