Fig. 6.

Aβ and tau interact in a synergistic manner to promote neuronal degeneration. a–c Retinal toxicity in flies expressing wild-type tau a, Aβ b and double-transgenic flies expressing wild-type tau and Aβ c. d Hematoxylin and eosin-stained frontal brain sections from flies expressing wild-type tau, Aβ or coexpressing wild-type tau and Aβ indicates that Aβ substantially enhances wild-type tau-induced neurodegeneration. Vacuolization of the neuropil (n) and cortex (cx) is indicated by arrows. Adapted by permission from Macmillan Publishers Ltd: Nature Cell Biology, (Fulga et al. 2007), copyright (2007)