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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Neuropharmacology. 2010 Jan 14;58(7):1002–1008. doi: 10.1016/j.neuropharm.2010.01.003

Figure 4.

Figure 4

Intact rats show no limb use asymmetry in the Cylinder test at baseline (BL). The unilateral 6-OHDA lesion (LX) impairs contralateral limb use. Chronic L-DOPA + vehicle for MK-801 causes a shift to contralateral limb use (see 0 mg/kg), but placements are qualitatively different than those observed when animals are not expressing AIMs, as described in the text. MK-801 dose-dependently restores behavior toward control levels. * p < 0.05 relative to BL, # p < 0.05 relative to LX.