Table 7.
Top meta-signature genes
| Age Down-regulated | Age Up-regulated | ||
|---|---|---|---|
| OLFM1 | olfactomedin 1 | NEBL | nebulette |
| KCNF1 | potassium voltage-gated channel, subfamily F, member 1 | MED12 | mediator complex subunit 12 |
| RGS4 | regulator of G-protein signaling 4 | BCL2 | B-cell CLL/lymphoma 2 |
| PPP3CB | protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform | GMPR | guanosine monophosphate reductase |
| ADCY2 | adenylate cyclase 2 (brain) | GFAP | glial fibrillary acidic protein |
| SVOP | SV2 related protein homolog (rat) | ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide |
| EFNB3 | ephrin-B3 | WWOX | WW domain containing oxidoreductase |
| ATP2B2 | ATPase, Ca++ transporting, plasma membrane 2 | PLEC1 | plectin 1, intermediate filament binding protein 500kDa |
| HPCA | hippocalcin | VCAN | versican |
| CALB1 | calbindin 1, 28kDa | AHCYL1 | S-adenosylhomocysteine hydrolase-like 1 |
| pH Down-regulated | pH Up-regulated | ||
| FGF2 | fibroblast growth factor 2 (basic) | SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| AHCYL1 | S-adenosylhomocysteine hydrolase-like 1 | LARGE | like-glycosyltransferase |
| DTNA | dystrobrevin, alpha | C17orf81 | chromosome 17 open reading frame 81 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | HISPPD2A | histidine acid phosphatase domain containing 2A |
| TJP1 | tight junction protein 1 (zona occludens 1) | PRKCD | protein kinase C, delta |
| S100A13 | S100 calcium binding protein A13 | DLG3 | discs, large homolog 3 (Drosophila) |
| RBBP6 | retinoblastoma binding protein 6 | KCNAB1 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 |
| GNG12 | guanine nucleotide binding protein (G protein), gamma 12 | SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | GABRA5 | gamma-aminobutyric acid (GABA) A receptor, alpha 5 |
| BAALC | brain and acute leukemia, cytoplasmic | RIT2 | Ras-like without CAAX 2 |
| Female Up-regulated | Male Up-regulated | ||
| XIST | X (inactive)-specific transcript (non-protein coding) | JARID1D | jumonji, AT rich interactive domain 1D |
| HDHD1A | haloacid dehalogenase-like hydrolase domain containing 1A | USP9Y | ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila) |
| UTX | ubiquitously transcribed tetratricopeptide repeat, X chromosome | EIF1AY | eukaryotic translation initiation factor 1A, Y-linked |
| JARID1C | jumonji, AT rich interactive domain 1C | CYorf15B | chromosome Y open reading frame 15B |
| TSIX | XIST antisense RNA (non-protein coding) | DDX3Y | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked |
| USP9X | ubiquitin specific peptidase 9, X-linked | UTY | ubiquitously transcribed tetratricopeptide repeat gene, Y-linked |
| LOC554203 | alanyl-tRNA synthetase domain containing 1 pseudogene | RPS4Y1 | ribosomal protein S4, Y-linked 1 |
| STS | steroid sulfatase (microsomal), isozyme S | TTTY15 | testis-specific transcript, Y-linked 15 |
| ZFX | zinc finger protein, X-linked | CYorf15A | chromosome Y open reading frame 15A |
| PNPLA4 | patatin-like phospholipase domain containing 4 | TMSB4Y | thymosin beta 4, Y-linked |
| PMI Down-regulated | PMI Up-regulated | ||
| BRD8 | bromodomain containing 8 | GOSR2 | golgi SNAP receptor complex member 2 |
| RBM5 | RNA binding motif protein 5 | CYB5B | cytochrome b5 type B (outer mitochondrial membrane) |
| PUM2 | pumilio homolog 2 (Drosophila) | SNF8 | SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | GRLF1 | glucocorticoid receptor DNA binding factor 1 |
| NCOA3 | nuclear receptor coactivator 3 | C6orf1 | chromosome 6 open reading frame 1 |
| DAPK1 | death-associated protein kinase 1 | MGMT | O-6-methylguanine-DNA methyltransferase |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats-containing | MAX | MYC associated factor X |
| KIAA0841 | KIAA0841 | ST3GAL2 | ST3 beta-galactoside alpha-2,3-sialyltransferase 2 |
| CAMK2G | calcium/calmodulin-dependent protein kinase II gamma | PTGER3 | prostaglandin E receptor 3 (subtype EP3) |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | EXT1 | exostoses (multiple) 1 |
For each meta-signature we have listed the top ten genes, as ranked by meta-q-value (all at q < 0.001). For each gene we have listed the gene symbol an gene name. Complete meta-signature lists for each factor can be found in Supplementary Table 6 http://chibi.ubc.ca/~mmistry/.