Table 2.

DNA sequence features of RET/PTC3 breakpoints in post-Chernobyl tumors and their correspondence to specific DNA repair pathways

	NHEJ
			MMEJ		SSA
case ID*	microhomology at breakpoint	distant microhomology (less than 5 nt)	distant microhomology (5 or more nt)	Deletions at breakpoint	repeats in both genes	deleted repeats
C22	yes	yes	yes	yes	yes	2 copies
C82	no	yes	no	yes	yes	none
C102	yes	yes	yes	yes	yes	none
C112	no	yes	yes	no	yes	none
C142	yes	yes	yes	yes	yes	none
C152	yes	yes	yes	no	none	none
C172	no	yes	yes	no	none	none
C202	no	yes	no	yes	none	none
C242	yes	yes	no	yes	none	none
C272	yes	yes	no	yes	yes	2 copies
C282	yes	yes	yes	yes	none	none
C302	no	yes	no	yes	none	none
M2T1	yes	yes	no	yes	yes	1 copy
M12T1	yes	yes	no	yes	yes	1 copy
M80T1	yes	yes	yes	yes	yes	2 copies
M81T1	no	yes	yes	yes	yes	3 copies
M89T1	no	no	no	yes	yes	3 copies
M122T1	yes	yes	yes	yes	yes	1 copy
M129T1	no	yes	yes	yes	yes	none
M153T1	yes	yes	yes	yes	yes	1 copy
M161T1	yes	yes	yes	yes	yes	2 copies
M162T1	yes	yes	yes	yes	yes	1 copy
M190T1	yes	yes	yes	yes	none	none
M216T1	no	yes	yes	yes	yes	1 copy
M219T1	no	yes	yes	yes	none	none
M225T1	yes	yes	yes	yes	yes	1 copy
M259T1	yes	yes	yes	yes	yes	2 copies
M263T1	no	yes	yes	yes	yes	1 copy
CH43	no	yes	yes	yes	yes	1 copy
CH83	no	yes	yes	yes	none	none
CH103	no	yes	yes	no	yes	none

^*RET/PTC3 sequences reported by

¹Klugbauer et al. [85]

²Nikiforov et al. [86]

³Bongarzone et al. [87].