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. Author manuscript; available in PMC: 2010 Apr 6.
Published in final edited form as: Lab Chip. 2009 Sep 17;9(22):3275–3281. doi: 10.1039/b912097a

Fig. 2.

Fig. 2

Functional elements of multi-channel LOC system. An expanded single channel (A) where the sample reservoir (1) and the reagent reservoir (2) are joined via V junction (3) to the joining channel (4). The cleavage reaction is monitored in the detection wells (5) designed with air traps to minimize air bubbles, followed by a mixing trap (6). The full schematic of eight-channel LOC chip (B), including the eight channel negative pressure distribution splitter (7) connected to a waste chamber (8) to the outlet for a pump or syringe (9). The alignment holes (10) were designed to simplify fabrication. A clear PMMA LOC device (C) photographed with blue illumination to increase contrast.