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. 2009 Oct 1;297(6):G1147–G1162. doi: 10.1152/ajpgi.00295.2009

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Fig. 7. — Effect of the irreversible adenosine A1 receptor antagonist 8-cyclopentyl-N³-[3-(4-(fluorosulfonyl)benzoyloxy)propyl]-xanthine (FSCPX) or adenosine deaminase on I_sc/chloride secretion in the guinea pig distal colon. A: FSCPX caused a concentration-dependent augmentation of the I_sc response. B: concentration-response curve to FSCPX for enhancement of the I_sc response (n = 8, ANOVA, P < 0.001). The maximum effect of FSCPX was observed at a 1 μM concentration. C: adenosine deaminase augmented the I_sc response at 1 or 5 U/ml concentration. D: concentration-effect curve for the A3 agonist IB-MECA for inhibition of I_sc/chloride secretion in guinea pig distal colon. The IC₅₀ concentration of IB-MECA is 0.8 μM. FSCPX (1 μM) knockdown was used to eliminate possible interactions of IB-MECA with inhibitory A1 receptors; n = 8 (ANOVA, P < 0.0001).