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. 2009 Oct 8;297(6):G1259–G1267. doi: 10.1152/ajpgi.00177.2009

Fig. 12.

Fig. 12.

PI3K-dependent prevention of TLC-induced TC uptake inhibition by cAMP. A: HuH-NTCP cells were pretreated 100 μM CPT-cAMP for 15 min and then with the indicated concentrations of TLC before determining TC uptake. cAMP-dependent values represent the difference between TC uptake in the presence and absence of CPT-cAMP. *Significantly different (P < 0.05) from 0 μM TLC values in the absence of CPT-cAMP and #significantly different from respective values in the absence of CPT-cAMP. B: HuH-NTCP cells were pretreated with or without 100 μM cAMP for 15 min and 20 μM LY294002 for 20 min and then with TLC for 25 min before determining TC uptake. Values are means ± SE (n = 3–4); *significantly different (P < 0.05) from respective values in the absence of CPT-cAMP.