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. Author manuscript; available in PMC: 2010 Sep 10.
Published in final edited form as: Structure. 2010 Mar 10;18(3):332–342. doi: 10.1016/j.str.2010.01.003

Figure 1. The overall structure of the IL-13/IL-13Rα2 complex.

Figure 1

(A) Schematic representation of the IL-13 receptor family. S-Ig stands for s-type Ig domain, and CHR indicates the cytokine-binding homology region. Disulfide bonds in the receptors are represented by yellow lines. (B) The structure of the IL-13/IL-13Rα1/IL-4Rα signaling complex, (PDB ID 3BPO). (C–D) The structure of the IL-13/IL-13Rα2 complex. (C) Side and (D) face-on views of IL-13/IL-13Rα2. IL-13 helices A through D are colored yellow, and IL-13Rα2 domains 1 to 3 (D1–D3) are colored blue. The cytokine-receptor interaction sites II and III are highlighted in ovals. The single N-acetylglucosamine sugar residue attached to Asn215 is colored orange, and disulfide bonds are colored yellow.