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. Author manuscript; available in PMC: 2010 Sep 10.
Published in final edited form as: Structure. 2010 Mar 10;18(3):332–342. doi: 10.1016/j.str.2010.01.003

Figure 4. Comparison of the site II and site III interfaces for IL-13 in complex with IL-13Rα1 and IL-13Rα2.

Figure 4

To make comparisons between the two IL-13/receptor complexes, the IL-13 molecules were structurally superimposed. (A–D) Comparison of residues that comprise the site III and site II interfaces for IL-13Rα2 (A and C, in blue) and IL-13Rα1 (B and D, in green). Cytokine-interacting residues are shown as sticks. (E–F) “Projection” view of IL-13 helices A and D depicted as ribbons and sticks interacting with semi-transparent molecular surfaces of (E) IL-13Rα2 and (F) IL-13Rα1. Interacting residues are shown as sticks, with the key ‘hotspot’ residues I14, K104, and F107 colored pink.