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. Author manuscript; available in PMC: 2010 Sep 10.
Published in final edited form as: Structure. 2010 Mar 10;18(3):332–342. doi: 10.1016/j.str.2010.01.003

Figure 6. An IL-4/IL-13 hotspot mediates binding to the IL-13 receptor family.

Figure 6

The A and D helices of IL-13 molecules from our IL-13/IL-13Rα2 complex and the IL-13/IL-13Rα1 complex (PDB 3BPO) were aligned along with the A and D helices of IL-4 from the IL-4/IL-13Rα1 complex (PDB 3BPN). Side chains interacting with IL-13Rα1 or IL-13Rα2 are shown as stick models. The IL-13 receptor binding ‘hotspot’ consisting of the IL-13/IL-4 residues I14/I11, K104/R121, and F107/Y124 is highlighted.