Table 3.
(i) | 60%–80% of patients remain chronically infected and suffer consequences |
(ii) | Patients who do recover develop multiepitope-specific CD8+ and type 1 CD4+ T cells |
(iii) | Neutralizing Ab production takes 6–8 months and highest titers occur in chronics. Recovered patients may test negative |
(iv) | Abs always gone by 10–20 y, but specific T cells persist for life in liver (in chimps) |
(v) | Chimps without CD4+ or CD8+ T cells fail to control infection |
(vi) | Escape mutants for Ab and T cells occur readily |