Table 2.
Markers in IL10RB and IFNAR1 demonstrating evidence of association in the dominant model analysis.
| Marker | Genotype 11 versus 12 + 22§ | ||
|---|---|---|---|
| OR (95%CI) | Wald statistic | P | |
| IL10RB +1165 | 1.75 (1.25-2.50) | 10.21 | 0.001 |
| IL10RB +1797 | 1.69 (1.16-2.45) | 7.6 | 0.006 |
| IFNAR1 267717g-t | 1.39 (1.06-1.82) | 6.0 | 0.015 |
| IFNAR1 272354c-g | |||
| The Gambia | 1.5 (1.11-2.22) | 6.7 | 0.010 |
| Vietnam | 1.81 (1.17-2.82) | 7.0 | 0.005¶ |
| Kenya | 1.29 (1.00-1.66) | 4.05 | 0.022¶ |
|
| |||
| Combined populations | 1.38 (1.17-1.64) | 14.19† | 0.00017 |
|
| |||
| IFNAR1 279923c-t | 1.67 (1.18-2.38) | 8.38 | 0.004 |
| IFNAR1 283708a-g | 1.75 (1.22-2.50) | 9.39 | 0.002 |
¶
For both Vietnamese and Kenyan replication sets, the one tailed test was used.
†
Mantel-Haenszel 2×2 chi-squared statistic.
§
11 depict the wild-type homozygote genotype, 12 depict heterozygotes, and 22 depict homozygote mutants.
N/B: The previously described IFNAR1 +17470 and L168V demonstrate P=0.018 and P=0.031 respectively in the dominant model analysis [23].