Table 1. Proteins involved in resection in different eukaryotes.
| E. coli | P. furiosus | S. cerevisiae | S. pombe | H. sapiens | Function |
|---|---|---|---|---|---|
| RecBCD | Unk. | Unk. | Unk. | Unk. | DNA helicase, ATPase, 5′ exonuclease, 3′ exonuclease |
| SbcD | Mre11 | Mre11 | Rad32 | Mre11 | 3′–5′ exonuclease, endonuclease |
| SbcC | Rad50 | Rad50 | Rad50 | Rad50 | ATPase |
| Unk. | Unk. | Xrs2 | Nbs1 | Nbs1 | |
| Unk. | Unk. | Sae2 | Ctp1 | CtIP | ssDNA specific endonuclease |
| Unk. | Unk. | Unk. | Unk. | BRCA1 | Ubiquitin ligase |
| Unk. | Unk. | Exo1 | Exo1 | Exo1 | 5′–3′ exonuclease |
| RecQ | Hjma,b | Sgs1 | Rqh1a | RECQ1a,BLM, WRNa, RTSa, RECQ5 |
DNA helicases |
| RecJ | Several homologsa |
Unk. | Unk. | Unk. | 5′–3′ exonuclease |
| Unk. | Unk. | Dna2 | Dna2a | Dna2a | 5′ flap endonuclease, DNA helicase |
| Unk. | Unk. | Rad9 | Crb2a | 53BP1a | Checkpoint adaptor protein |
| Unk. | NurA | Unk. | Unk. | Unk. | 5′–3′ exonuclease |
| Unk. | HerA | Unk. | Unk. | Unk. | DNA helicase |
E. coli, Escherichia coli; P. furiosus, Pyrococcus furiosus; S. cerevisae, Saccharomyces cerevisiae; S. pombe, Schizosaccharomyces pombe; H. sapiens, Homo sapiens; Unk., unknown.
a
Not formally shown to be involved in DNA resection.
b
Despite the lack of RecQ sequence orthologs in Archea, Hjm can complement E. coli RecQ mutants.