Table 1.

Characteristics of participants in the seven community cohorts included in the meta-analysis of genome-wide association studies of PR. Exclusion criteria is given in Supplementary Table 1. “Participants after exclusion with genome-wide genotypes available” gives the N used in the analysis. Standard deviation (SD) of PR interval is given after adjustment for all covariates. ^fSamples are from the three generations of the Framingham Heart Study (G1=685, G2=3178, G3=3773).

	AGES	ARIC	CHS	FHS	KORA F3	KORA S4	Rotterdam	SardiNIA
N - participants before exclusion	3,219	11,478	2,084	12,174f	1,644	1,100	5,271	4,305
N - participants after exclusion with genome-wide genotypes available	2,471	6,486	1,769	7,636f	1,427	927	3,710	4,091
Sex, Men, n (%)	922 (37.3)	2,977 (45.9)	773 (43.7)	3,511 (46.0)	728 (51.0)	447 (48.2)	1,541 (39.8)	1,782 (43.5)
Age, years, mean	76.1 ± 5.4	53.9 ± 5.7	72.9 ± 5.4	39.9 ± 10.3	61.6 ± 9.9	56.2 ± 7.1	67.8 ± 8.5	42.5 ± 17.1
PR interval, ms, mean	171.4 ± 27.7	162.7 ± 23.7	167.9 ± 28.5	152.1 ± 21.9	163.3 ± 23.3	164.6 ± 21.2	165.9 ± 24.1	154.2 ± 26.7
RR interval, ms, mean ± SD	925.9 ± 156.5	915.7 ± 132.4	949.1 ± 155.5	905.7 ± 174.8	963.5 ± 160.6	930.7 ± 139.2	861.9 ± 137.4	921.2 ± 152.2
BMI, kg/m2, mean ± SD	27.1 ± 4.4	26.7 ± 4.7	26.5 ± 4.5	26.1 ± 4.9	28.0 ± 4.4	27.8 ± 4.5	26.1 ± 3.5	25.2 ± 4.6
Height, cm, mean ± SD	166.4 ± 9.1	168.8 ± 9.4	164.9 ± 9.6	169.1 ± 9.5	167.1 ± 9.1	167.4 ± 8.8	167.3 ± 9.3	160.1 ±8.9
Systolic BP, mmHg, mean ± SD	143 ± 20	117.2 ± 16.3	137 ± 21	120 ± 15	134 ± 20	132 ± 19	139 ± 22	125 ± 18
Beta-Blockers (%)	780 (31.6)	Excluded	176 (10.0)	Excluded	283 (19.8)	99 (10.7)	Excluded	Excluded
Diuretics (%)	733 (29.7)	562 (8.7)	434 (24.5)	ND	273 (19.1)	76 (8.2)	292 (7.5)	45 (1.1)
Calcium Antagonists* (%)	131 (5.3)	Excluded	78 (4.4)	Excluded	ND	ND	Excluded	Excluded
SD of PR residual after adjustment for covariates, ms	25.9	23.0	26.9	20.5	21.3	20.1	23.0	25.5