Table 3.
Characteristics of participants included in the meta-analysis of the association of the nine significant PR loci with atrial fibrillation. Overall the CHARGE prevalent AF sample included 896 cases, the CHARGE incident AF sample included 2,517 cases and the case-control sample included 2,328 cases aThe n given is the number of participants in the CHARGE cohorts and the number of cases plus controls in case control studies, bAge was defined as age at DNA collection. BMI: body mass index; NA: age at onset of prevalent AF not available for CHS and RS.
| Baseline Characteristics | CHARGE studies: Prevalent AF Analysis | CHARGE studies: Incident AF Analysis | Case Control Studies: Prevalent AF Analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AGES | CHS | FHS | RS | AGES | ARIC | CHS | FHS | RS | AFNET | CCAF | |
| Participants | |||||||||||
| na | 2,959 | 3,267 | 4,464 | 5,974 | 2,718 | 8,086 | 3,201 | 4,184 | 5,665 | 6,218 | 347 |
| Sex, men, n (%) |
1,154 (39.0) |
1,278 (39.1) |
2,004 (44.9) |
2,427 (40.6) |
1,011 (37.2) |
3,814 (47.2) |
1,241 (38.8) |
1,830 (43.7) |
2,282 (40.3) |
3,569 (57.4) |
202 (58.2) |
| Ageb, years, mean (SD) | 76.5 (5.5) | 72.3 (5.4) | 65.5 (12.7) | 69.4 (9.1) | 76.3 (5.5) | 57.0 (5.7) | 72.2 (5.3) | 64.7 (12.6) | 69.1 (9.0) | 52.7 (14.0) | 56.4 (8.2) |
| Ageb, years, min-max | 66-95 | 65-98 | 30-100 | 55-99 | 66-95 | 46-70 | 65-98 | 30-100 | 55-99 | 14-93 | 20-88 |
| Hypertension, n (%) |
2,260 (79.8) |
1,711 (52.4) |
2,263 (50.8) |
1,997 (33.4) |
2,145 (78.9) |
2192 (27.1) |
1,677 (52.4) |
2,062 (49.4) |
1,866 (32.9) |
1,902 (30.6) |
151 (43.5) |
| Cases | |||||||||||
| Atriial fibrillarion cases | 241 | 66 | 280 | 309 | 138 | 731 | 763 | 343 | 542 | 2,145 | 183 |
| Age at AF onset, mean (SD) | 76.9 (6.0) | NA | 70.6 (10.6) | NA | 80.6 (6.0) | 67.0 (6.7) | 81.2 (6.0) | 77.4 (10.5) | 77.7 (7.7) | 59.7 (11.2) | 46.0 (11.0) |