Table 4.

Meta-analytic results for the association of the nine significant PR loci with atrial fibrillation. Meta-analyzed were results from a meta-analysis of prevalent AF conducted in the CHARGE cohorts, results from a meta-analysis of incident AF conducted in the CHARGE cohorts, results from the AFNET case-control study and results from the CCAF case-control study. The Bonferroni adjusted table-wide significance threshold is P= 0.05/9= 5.6E-03, the p(adjusted) column reports the significance thresholds after adjustment for 9 tests. For all five SNPs we identified as associated with AF the minor allele decreased the risk of AF irrespective of the direction of its effect on PR interval.

Nearest gene	SNP	Chr	pos build36	PR prolonging allele	Frequency – PR prolonging allele	OR for AF – PR prolonging Allele	OR for AF – 95% CI lower bound	OR for AF – 95% CI upper bound	P (unadjusted)	P (adjusted)	Effect of PR prolonging allele towards AF risk	Effect of minor allele towards AF risk
MEIS1	rs11897119	2	66,625,504	C	0.39	1.01	0.97	1.06	0.65	-	ns	ns
SCN5A	rs11708996	3	38,608,927	C	0.15	0.90	0.84	0.96	7.0E-04	6.30E-03	Decreased	Decreased
SCN10A	rs6800541	3	38,749,836	C	0.40	0.92	0.88	0.96	1.5E-04	1.35E-03	Decreased	Decreased
ARHGAP24	rs7692808	4	86,860,173	G*	0.69	1.01	0.97	1.06	0.56	-	ns	ns
NKX2-5	rs251253	5	172,412,942	T*	0.61	1.07	1.03	1.12	2.3E-03	2.07E-02	Increased	Decreased
CAV1/CAV2	rs3807989	7	115,973,477	A	0.40	0.91	0.87	0.95	2.2E-05	1.98E-04	Decreased	Decreased
WNT11	rs4944092	11	75,587,267	A*	0.67	0.94	0.90	0.99	0.01	-	ns	ns
SOX5	rs11047543	12	24,679,606	G*	0.85	1.13	1.06	1.20	2.1E-04	1.89E-03	Increased	Decreased
TBX5/TBX3	rs1896312	12	113,830,807	C	0.30	0.99	0.95	1.04	0.72	-	ns.	ns.