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Schematic representation depicting the effects of HGF/c-met actions on glycolysis (10), phosphorylation of Akt, Bad, AMPK and ACC, FFA oxidation, SPT up-regulation, ceramide accumulation, and apoptosis in the β-cell in the presence of an excess of palmitate in the extracellular milieu. Glut-2, Glucose transporter-2; CL, citrate lyase; TG, triglycerides; DAG, diacylglycerols.
