Table 1.
Gene expression patterns in mouse aorta: Prioritized list of potential PPARγ targets up-regulated by rosiglitazone.
| ProbeSet | rosiglitazone | gdn | Gene | Description | |||
|---|---|---|---|---|---|---|---|
| low2d | low14d | high2d | high14d | ||||
| 1424451_at | 3.14 | 3.33 | 4.41 | 7.64 | 0.23 | Acaa1b | Acetyl-Coenzyme A acyltransferase 1B |
| 1451679_at | 2.03 | 1.51 | 2.12 | 2.09 | 0.41 | 6530401D17Rik | RIKEN cDNA 6530401D17 gene |
| 1428333_at | 2.71 | 1.82 | 3.01 | 2.83 | 0.42 | 2900062L11Rik | RIKEN cDNA 2900062L11 gene |
| 1436233_at | 2.25 | 2.17 | 2.44 | 4.58 | 0.43 | AI117581 | Expressed sequence AI117581 |
| 1449218_at | 2.20 | 2.13 | 1.51 | 2.64 | 0.46 | Cox8b | Cytochrome c oxidase, subunit VIIIb |
| 1449461_at | 3.51 | 2.75 | 3.97 | 6.88 | 0.48 | Rbp7 | Retinol binding protein 7, cellular |
| 1416023_at | 1.47 | 1.82 | 1.21 | 2.50 | 0.54 | Fabp3 | Fatty acid binding protein 3, muscle and heart |
| 1448499_a_at | 1.69 | 1.61 | 1.71 | 2.34 | 0.60 | Ephx2 | Epoxide hydrolase 2, cytoplasmic |
| 1448382_at | 1.77 | 1.32 | 1.54 | 1.85 | 0.66 | Ehhadh | Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme |
| 1454067_a_at | 1.57 | 1.56 | 1.71 | 1.93 | 0.66 | 4931406C07Rik | RIKEN cDNA 4931406C07 gene |
| 1431789_s_at | 1.40 | 1.41 | 1.51 | 1.57 | 0.68 | Tmed5 | Transmembrane emp24 protein transport domain |
| 1447558_at | 1.40 | 1.10 | 1.56 | 0.97 | 0.70 | Atxn7l4 | Ataxin 7-like 4 (Atxn7l4), mRNA |
| 1428435_at | 1.16 | 1.18 | 1.40 | 1.38 | 0.70 | Muc2 | Mucin 2 |
| 1453592_at | 1.20 | 1.22 | 1.42 | 1.44 | 0.71 | Lrrc39 | Leucine rich repeat containing 39 |
| 1417023_a_at | 1.71 | 1.64 | 1.86 | 1.90 | 0.71 | Fabp4 | Fatty acid binding protein 4, adipocyte |
| 1444063_at | 1.24 | 1.10 | 1.32 | 1.32 | 0.74 | 5430435G22Rik | RIKEN cDNA 5430435G22 gene |
| 1445802_at | 1.22 | 1.30 | 1.35 | 1.26 | 0.76 | AU017455 | Expressed sequence AU017455 |
| 1441306_at | 0.98 | 1.21 | 1.21 | 1.07 | 0.78 | 6820408C15Rik | RIKEN cDNA 6820408C15 gene |
| 1420571_at | 1.06 | 1.20 | 1.24 | 1.10 | 0.80 | Prlpb | Prolactin-like protein B |
| 1442980_at | 1.18 | 1.23 | 1.25 | 1.00 | 0.80 | Srpk2 | Serine/arginine-rich protein specific kinase 2 |
| 1446574_at | 1.37 | 1.18 | 1.30 | 1.27 | 0.80 | Ncor1 | Nuclear receptor co-repressor 1 |
| 1423578_at | 1.23 | 1.26 | 1.25 | 1.37 | 0.81 | Col11a2 | Procollagen, type XI, alpha 2 |
| 1443670_at | 1.24 | 1.24 | 1.27 | 1.27 | 0.81 | 2010001J22Rik | RIKEN cDNA 2010001J22 gene |
| 1433238_at | 1.06 | 1.21 | 1.22 | 1.17 | 0.81 | 4930448E06Rik | RIKEN cDNA 4930448E06 gene |
| 1441211_at | 1.14 | 1.24 | 1.29 | 1.25 | 0.82 | Kcns2 | K+ voltage-gated channel, subfamily S, 2 |
| 1426391_at | 1.01 | 1.23 | 1.25 | 1.30 | 0.83 | LOC545267 | Similar to ADP-ribosylation factor 1 |
| 1437646_at | 1.18 | 1.22 | 1.25 | 1.19 | 0.83 | LOC631806 | Similar to Goliath homolog precursor (Ring finger |
| 1450736_a_at | 1.31 | 1.05 | 1.21 | 0.92 | 0.85 | Hbb-bh1 | Hemoglobin Z, beta-like embryonic chain |
Bold indicates statistical significance. Low and high correspond to rosiglitazone doses of 3 and 10 mg/kg/day, respectively. G-DN mice contain a globally expressed dominant negative isoform of PPARγ.