Table 3.

Association of differentially expressed genes with experimentally determined PPARγ binding sites.

Group	Total	PPRE+	PPRE-	PPRE+ %	p-value
RZ up # changes >= 1	117	34	83	29.06	2.50E-06
RZ up # changes >= 2	65	25	40	38.46	1.57E-07
RZ up # changes >= 3	26	15	11	57.69	7.14E-08
RZ up # changes >= 4	12	11	1	91.67	1.49E-09
RZ down # changes >= 1	706	89	617	12.61	5.33E-01
RZ down # changes >= 2	369	52	317	14.09	2.30E-01
RZ down # changes >= 3	143	24	119	16.78	9.29E-02
RZ down # changes >= 4	12	0	12	0.00	1.00E+00
RZ up and G-DN down (Table 1)	7	7	0	100.00	5.31E-07
RZ down and G-DN up (Table 2)	10	1	9	10.00	7.42E-01
Genes expressed in aorta and 3T3-L1 adipocytes	8661	1096	7565	12.65	NA

RZ = rosiglitazone, G-DN = mice with dominant negative PPARγ, up = up-regulated, down = down-regulated.