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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Bioorg Med Chem. 2010 Feb 11;18(7):2756–2766. doi: 10.1016/j.bmc.2010.02.013

Figure 3.

Figure 3

Activity and physicochemical property summary sorted by therapeutic index. Antimalarial activity is represented as the EC50 value in green, with darker squares indicating higher potency. Cytotoxicity data is represented as the percentage cell death relative to untreated control at a fixed 27.5 μM screening concentration in orange, with lighter squares indicating more cell death. The therapeutic index is represented as a ratio of the cytotoxicity value in HEK 293 cells to the EC50 in the K1 strain in blue, with darker squares indicating higher potency (LD50 in HEK 293 cells applied to estimate the therapeutic index.). Permeability (PAMPA) at pH 7.4 is represented in purple, with darker squares indicating higher permeability. Solubility is represented in yellow, with darker squares indicating higher solubility.