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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Bioorg Med Chem. 2010 Feb 11;18(7):2756–2766. doi: 10.1016/j.bmc.2010.02.013

Scheme 2. Synthesis of 3-carboxylic acid and 3-carboxylic amide quinolones.

Scheme 2

a Reagents and conditions: a) NaOH (1 N, aqueous), 130 °C, overnight; b) KOH (1 N, aqueous), 75 °C, overnight; c) N,N′-carbonyldiimidazole, DMF, 65 °C, 2.5 h, NH4OH (aqueous), rt, overnight.