Table 2.
Multivariate Cox's regression hazard analyses
| Survivin protein-level | Cytoplasm | Nucleus | ||||
|---|---|---|---|---|---|---|
| N | RR | P | N | RR | P | |
| Svv weak (IRS = 3-4) | 15 | reference | 10 | reference | ||
| Svv negative(IRS = 0-2) | 8 | 4.2 | 0.055 | 29 | 3.1 | 0.110 |
| Svv moderate (IRS = 6-8) | 19 | 5.7 | 0.004 | 11 | 5.7 | 0.022 |
| Svv strong (IRS = 9-12) | 8 | 2.4 | 0.241 | none | ||
| Combined Svv protein levels | ||||||
| Svv cytopl. & nucleus weak (IRS = 3-4)1 | 6 | reference | ||||
| Svv all other cases | 35 | 9.4 | 0.024 | |||
| Svv cytopl. & nucleus moderate+strong (IRS ≥ 6)2 | 9 | 24.8 | 0.003 | |||
Correlation of survivin expression in cytoplasm and/or nucleus with prognosis of leiomyosarcoma and synovial sarcoma patients.
Significant results are in bold face; 1Survivin expression both in cytoplasm and in nucleus weak (all IRS = 3-4); 2Survivin expression in cytoplasm moderate or strong and survivin expression in nucleus moderate (all IRS ≥ 6)
Abbreviations: Svv-survivin; IRS-immunoreactive score; cytopl.-cytoplasma