Figure 4.

A step by step protocol applied on day 5 post infection for predicting CM. Item₅ and Item+P₅ scores should be used estimate the probability of CM development on any time between days 6 - 10 post infection. Item²⁴ and Item+P²⁴ should be used to estimate the probability of CM development on day 6 post infection (24 hours after day 5 post infection). SHIRPA tests and its respective weights compounding each score are shown in the third line. Values obtained for each SHIRPA test should be multiplied by its respective weight and summed up to get a final score. A final score above or equal (≥) this value is considered positive and is associated with a high probability of cerebral malaria (CM) development. On the other hand, a final score under this value (<) is considered negative and is associated with a low probability of CM. RIJ = Rearing in Jar; U = Urination; BP = Body Position; RRa = Respiration Rate; T = Tremor; RIA = Rearing in Arena; G = Gait; PP = Positional Passivity; TC = Trunk Curl; LG = Limb Grasping; GS = Grip Strength; TP = Toe Pinch; WM = Wire Manoeuvre; SC = Skin colour; AT = Abdominal Tone; RR = Righting Reflex; NG = Negative Geotaxis; P = Parasitemia.