Table 2. Surrogate markers for extravascular hemolysis and disease severity on admission.
| Total study population (n = 91) | Group MM (n = 52) | Group SMA (n = 39) | p-valuea | |
| Pigment in Monocytes (%) | 10 (4–20) | 6 (2–10) | 19 (9–28) | <0.0001 |
| Relative spleen volume | 2.7 (2.0–3.8) | 2.5 (1.9–3.1) | 3.0 (2.5–4.2) | <0.05 |
| Spleen (cm) | 2 (0–3) | 1 (0–2) | 2 (2–4) | <0.0001 |
| Neopterin (ng/ml) | 7.2 (5.7–9.9) | 6.5 (5.3–8.6) | 8.1 (6.4–12.3) | <0.05 |
| Lactate (mmol/l) | 2.6 (2.0–3.3) | 2.3 (1.8–2.9) | 2.9 (2.3–4.3) | <0.005 |
| sMODS | 14 (13–15) | 13 (12–14) | 15 (14–17) | <0.0001 |
MM: mild malaria, SMA: severe malarial anemia, relative spleen volume: calculated as spleen volume at recruitment/spleen volume after reconvalescence (measured by sonography), Spleen (cm) represents subcoastal spleen enlargement, sMODS: simplified multi organ dysfunction score, results are in median (interquartile ranges).
a
Kruskal-Wallis rank sum test.