Table 2. Summary of pooled single-locus associations observed in the ADORA2A gene.
| Assay | Coordinate | 1Test Variant | OR (95% CI) | Z-value (Pr) |
| rs3761422 | 23151226 | T (C) | 1.09 (0.99–1.21) | 1.67 (0.096) |
| TT (CC) | 1.19 (0.92–1.54) | 1.32 (0.187) | ||
| CT (CC) | 1.04 (0.90–1.19) | 0.51 (0.611) | ||
| rs2267076 | 23155149 | T (C) | 1.11 (1.00–1.23) | 1.95 (0.051) |
| TT (CC) | 1.30 (0.99–1.71) | 1.89 (0.058) | ||
| CT (CC) | 1.04 (0.91–1.20) | 0.56 (0.573) | ||
| rs9624472 | 23159285 | G (A) | 1.22 (1.09–1.37) | 3.38 (0.001) |
| GG (AA) | 1.60 (1.31–2.27) | 2.65 (0.008) | ||
| AG (AA) | 1.17 (1.02–1.36) | 2.18 (0.029) | ||
| rs5751876 | 23161855 | C (T) | 1.12 (1.02–1.23) | 2.26 (0.024) |
| CC (TT) | 1.26 (1.01–1.57) | 2.03 (0.042) | ||
| CT (TT) | 1.03 (0.89–1.20) | 0.45 (0.652) |
Results refer to allele and genotype-based associations pooled across the four studies: Gambia case-control, Gambia trios, Malawi case-control, and Malawi trios.
1
The test variant is followed by the alternative variant in brackets. Odds ratios refer to the effect of the test variant. Significant z-values (P<0.05) are presented in bold, trends of association (0.05≤P≤0.1) are presented in regular font, and non-significant associations (P>0.1) are presented in dark grey. Cochran's Q-test for heterogeneity on 4 degrees of freedom P>0.05 in all tests.