Figure 2.
(A) Development of PTZ (33 mg·kg−1·day−1, i.p.)-induced seizure to the fully kindled state. Data are mean ± SD (n= 10). (B) Anti-epileptic activity of PB during PB treatment. PTZ was given to kindled rats 40 min after oral administration of PB (45 mg·kg−1·day−1). Seizure stage and times were observed. Seizure indexes of PTZ-kindled model group (PTZ-CT rats) and PB treatment group (PTZ-PB rats) are presented. Index of seizure was defined as seizure stages × seizure times. Data are mean ± SD (n= 5). *P < 0.05, **P < 0.01 versus PTZ-CT rats using Student's t-test. PB, phenobarbital; PTZ, pentylenetetrazole.