Figure 3.
Effects of kindling and PB treatment on Rho123 distribution in plasma (A), cerebral cortex (B) and hippocampus (C). The treated kindled rats (PTZ-PB rats) and age-matched treated rats (PB-CT rats) were given PB (45 mg·kg−1·day−1, p.o.) for 14 or 40 consecutive days. Age-matched control rats (CT rats) and untreated kindled rats (PTZ-CT rats) only received 0.25% CMC-Na. The concentrations of Rho123 in plasma, cerebral cortex and hippocampus were measured 1 h after injection of Rho123 (0.2 mg·kg−1, i.v.). Each value is presented as mean ± SD (n= 8). *P < 0.05, **P < 0.01 versus CT rats and ##P < 0.01 versus PTZ-CT rats using one-way anova following by Student–Newman–Keuls multiple comparison post hoc test. PB, phenobarbital; PTZ, pentylenetetrazole; Rho123, rhodamine 123.