Figure 6.
Effects of kindling and PB treatment on P-GP mdr1a/mdr1b mRNA levels in the cerebral cortex. The treated kindled rats (PTZ-PB rats) and age-matched treated rats (PB-CT rats) were given PB (45 mg·kg−1·day−1, p.o.) for 14 or 40 consecutive days. Age-matched control rats (CT rats) and untreated kindled rats (PTZ-CT rats) only received 0.25% CMC-Na. Expression of P-GP mdr1a (A) and mdr1b (C) mRNA in the cerebral cortex and relative staining intensity for mdr1a (B) and mdr1b (D) mRNA in hippocampus are shown. Data are presented as mean ± SD (n= 4). *P < 0.05, **P < 0.01 versus CT rats and #P < 0.05, ##P < 0.05 versus PTZ-CT rats using anova statistics following by Student–Newman–Keuls multiple comparison post hoc test. CMC-Na, carboxymethylcellulose sodium; P-GP, P-glycoprotein; PB, phenobarbital; PTZ, pentylenetetrazole.