Table 1.

SNPs Associated at p < 10⁻⁵ with VT in the GWAS Scan and Their Replication in the Independent MARTHA and FARIVE Studies

Chr.	Gene(s)	rsID	Position	Alleles	GWAS			MARTHA			FARIVE
					MAFa		p Valueb	MAFa		p Valueb	MAFa		p Valueb
					Controls (n = 1228)	Cases (n = 419)		Controls (n = 801)	Cases (n = 1129)		Controls (n = 607)	Cases (n = 607)
1p34.2	PTPRF	rs11210892	43 872 671	A/G	0.32	0.40	6.70 × 10−6	0.32	0.37	1.83 × 10−3	0.33	0.33	0.811
3q26.31	TNIK	rs10936688	172 656 249	A/G	0.36	0.44	3.15 × 10−6	0.39	0.37	0.187
6p24.1	HIVEP1	rs169713	12 028 503	T/C	0.21	0.28	7.24 × 10−6	0.23	0.29	2.08 × 10−5	0.21	0.24	0.089
		rs9380643	12 038 473	C/T	0.22	0.30	2.44 × 10−6	0.24	0.31	1.98 × 10−6	0.24	0.26	0.227
7p15.3	IL6/TOMM7	rs10229457	22 767 325	G/A	0.29	0.38	1.05 × 10−6	0.34	0.36	0.128	-	-	-
8p21.3	ATP6V1B2/LZTS1	rs952148	20 135 799	C/T	0.11	0.06	1.35 × 10−6	0.10	0.11	0.459	-	-	-
12p12.1	ST8SIA1	rs2268861	22 280 741	G/A	0.32	0.24	1.82 × 10−6	0.31	0.29	0.231	-	-	-
16q22.1	NFATC3	rs12598	66 783 016	G/A	0.08	0.04	7.64 × 10−6	0.06	0.05	0.074	-	-	-
22q13.31	Gene desert	rs4823511	46 823 885	A/G	0.24	0.16	5.45 × 10−6	0.22	0.21	0.421	-	-	-

SNPs that did not pass the genome-wide significance level of 1.71 × 10⁻⁷ but showed suggestive evidence of association (p < 10⁻⁵) were investigated in the MARTHA study. SNPs that passed the Bonferroni-corrected significance level (p < 5.6 × 10⁻³) in MARTHA were further tested for association with VT in FARIVE.

^aMAF, minor allele frequency.

^bp values of the Cochran-Armitage trend test.