Table 2.
Top Replication Association P Values in the PUWMa Replication Sample
| SNP | Location | Gene | MAF | IMAGE New Screen P Value | Replication P Value |
|---|---|---|---|---|---|
| rs4369599 | 15 | NA | 0.245 | 0.017 | 0.00033 |
| rs200654 | 20 | TSHZ2 (MIM 128553) | 0.432 | 0.048 | 0.00082 |
| rs931671 | 17 | NDEL1 (MIM 607538) | 0.382 | 0.034 | 0.00095 |
| rs4257183 | 15 | NA | 0.123 | 0.015 | 0.00113 |
| rs7947031 | 11 | NA | 0.172 | 0.025 | 0.00170 |
| rs4234306 | 3 | NA | 0.470 | 0.009 | 0.00188 |
| rs16904936 | 8 | ST3GAL1 (MIM 607187) | 0.025 | 0.031 | 0.00189 |
| rs11706690 | 3 | CHL1 (MIM 607416) | 0.356 | 0.001 | 0.00204 |
| rs9912168 | 17 | NA | 0.335 | 0.009 | 0.00209 |
| rs2088108 | 1 | NA | 0.140 | 0.040 | 0.00239 |
| rs9644708 | 8 | TNKS (MIM 603303) | 0.203 | 0.030 | 0.00255 |
| rs2255672 | 18 | MRO (MIM 608080) | 0.272 | 0.026 | 0.00261 |
| rs220597 | 12 | GRIN2B (MIM 138252) | 0.348 | 0.037 | 0.00269 |
| rs1661281 | 10 | ANKRD22 (MIM 52024) | 0.305 | 0.043 | 0.00270 |
| rs1504508 | 18 | NA | 0.245 | 0.025 | 0.00291 |
| rs10109988 | 8 | NA | 0.276 | 0.038 | 0.00296 |
| rs17829444 | 14 | RAD51L1 (MIM 602948) | 0.201 | 0.029 | 0.0031 |
| rs210837 | 17 | NA | 0.075 | 0.045 | 0.0031 |
| rs1895699 | 2 | NA | 0.238 | 0.049 | 0.0031 |
| rs2149698 | 13 | NA | 0.406 | 0.020 | 0.0033 |
This table lists the SNPs with the strongest genetic associations in the PUWMa replication sample. Note that the genotyping platforms for the initial and replication samples were different, and as such there were a substantial number of SNPs that were dropped from this comparison. The replication association p values are listed from lowest to highest along with relevant information about the SNP, including the chromosomal location, whether it lies within a gene, the minor allele frequency, and the initial IMAGE new screen p values. NA denotes not available.