Table V.
pH-Responsive Polymers and Their Application in Drug Delivery
| Polymer | Drug delivery and other biomedical applications | References |
|---|---|---|
| Methacrylic acid copolymers | ||
| Eudragit® L100-55 (pH 5.5) | Mesalazine | (87) |
| Eudragit® P-4135F | Ellagic acid | (88) |
| Poly(GMD-PAA) | 5-aminosalicylic acid | (89) |
| Poly(HEMA–MAA) copolymer | Indomethacin and ephedrine HCl | (90) |
| Poly(MAA–EA) | Procaine HCl and imipramine HCl | (91) |
| Poly(MMA–DMA) | Aminopyrine, caffeine, and theobromine | (46) |
| PEG-b-poly(AlA-co-MA) | Fenofibrate and progesterone | (92) |
| Poly(HEMA) gels | Salicylic acid | (93) |
| Poly(HEMA) | Oral insulin, theophylline, proxyphylline oxprenolol, insulin, and protamine | (94) |
| (95) | ||
| Poly(EA–MAA–BDDA) and Poly(MMA–MAA–EGDMA) | Biomaterials for structural support of soft connective tissues | (96) |
| PEG-b-P(AlA-co-tBMA) block copolymers | Poorly water-soluble drugs: indomethacin, fenofibrate, progesterone | (97) |
| (98) | ||
| Poly(HEMA-co-MAA) hydrogels | Phenylpropanolamine | (99) |
| PEG-b-poly(AlMA-co-methacrylic acid) | Candesartan, cilexetil | (100) |
| Poly(acrylate) derivatives | ||
| PA-g-guar gum | Diltiazem HCl and nifedipine | (86) |
| NPA | Folic acid | (101) |
| Alginate derivatives | ||
| Alginate-guar gum hydrogel | Delivery of proteins and peptides (BSA) | (102) |
| Chitosan | ||
| CHT-TEOS | Lidocaine HCl, sodium salicylate, and 4-acetamidophenol | (41) |
| Polyphosphazenes | ||
| Polyphosphazene-PS polyphosphazene-polysiloxane polyphosphazene-ROMP of norbornene copolymers | No drug delivery application (a dye) Biebrich Scarlet was used to test release from these copolymers | (103) |
| (104) | ||
GMD glycidyl methacrylate dextran, HEMA hydroxyethyl methacrylate, MMA methyl methacrylate, DMA dimethylaminoethyl methacrylate, ATRP atom transfer radical polymerization, AlA alkyl acrylate, HEMA 2-hydroxyethyl methacrylate, EGDMA ethylene glycol dimethacrylate, PA polyacrylamide, NPA p-nitrophenyl acrylate, TEOS tetra ethyl ortho silicate, tBMA t-butyl methacrylate, PAA poly(acrylic acid), MAA methacrylic acid, EA ethyl acrylate, PEG poly(ethylene glycol), BDDA butanediol diacrylate, EG ethylene glycol, MA methacrylamide, CL caprolactone, PVP poly(N-vinylpyrrolidone), CHT chitosan, PS polystyrene, AlMA alkyl (meth)acrylate