Fig. 3.

The tendency of ketoconazole and miconazole to remain solubilized after dilution. Solvent systems comprising 0.1% polysorbate 80, 20% ethanol, and ammonium acetate (pH 3.1) and 100, 75 and 50 mg/mL ketoconazole and 30, 20, and 10 mg/mL miconazole were diluted tenfold with 0.9% sodium chloride infusion to reach final concentrations of 10 mg/mL, 7.5 mg/mL, and 5 mg/mL for ketoconazole and 3 mg/mL, 2 mg/mL and 1 mg/mL for miconazole