Table I.
Comparison of Flow Rates (in Cubic Millimeters per Second and Milligrams per Second) and Carr’s Index of the Excipients Tested (n = 3)
| Excipient | Flow rate (mm3/s) | Flow rate (mg/s) | RH (%) | Carr’s index (%) | RH (%) |
|---|---|---|---|---|---|
| Sugars | |||||
| Lactose monohydrate 80 M | 90.8 (3.5) | 63.8 (2.7) | 55–56 | 13.1 (0.1) | 52 |
| Lactose monohydrate 200 M | 10.1 (0.7) | 4.0 (0.3) | 55–56 | 24.9 (0.5) | 54 |
| Glucose anhydrate | 130.9 (0.4) | 100.8 (1.4) | 55–56 | 14.3 (0.8) | 57 |
| Xylitol | 31.5 (1.6) | 24.2 (1.3) | 55–56 | 13.6 (1.0) | 53 |
| Sorbitol | 179.5 (3.5) | 101.4 (2.2) | 55–56 | 10.1 (0.9) | 50 |
| Mannitol | 99.4 (8.1) | 48.8 (4.3) | 55–56 | 10.9 (0.6) | 54 |
| Sucrose | 227.6 (31.9) | 195.6 (26.2) | 55–56 | 7.9 (1.1) | 57 |
| Celluloses | |||||
| Avicel PH–101 | 85.1 (3.1) | 22.9 (0.6) | 55–56 | 18.9 (1.4) | 63 |
| Avicel PH–102 | 195.1 (31.2) | 64.2 (10.6) | 55–56 | 16.3 (1.4) | 60 |
| Avicel PH-200 | 166.4 (4.0) | 55.4 (1.3) | 55–56 | 14.8 (1.2) | 59 |
| Starches | |||||
| Native maize starch | 37.7 (2.7) | 16.8 (1.1) | 55–56 | 17.2 (2.6) | 63 |
| Native potato starch | 80.5 (2.1) | 51.5 (1.2) | 55–56 | 12.8 (1.2) | 56 |
| Pregelatinized maize starch (Starch 1500) | 239.2 (14.0) | 137.6 (5.0) | 46 | 18.0 (2.3) | 59 |