Table II.
The Mean Dimensions and Hardness Values for Different Tablet Formulas
| Parameter | Formula no. | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | ||||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| Diameter (mm) | 13.09 | 0.01 | 13.05 | 0.02 | 13.08 | 0.01 | 13.07 | 0.01 | 13.02 | 0.01 | 13.03 | 0.02 | 13.01 | 0.01 |
| Thickness (mm) | 3.24 | 0.01 | 3.39 | 0.03 | 3.25 | 0.02 | 3.12 | 0.02 | 2.55 | 0.03 | 2.53 | 0.02 | 2.46 | 0.01 |
| Hardness (N) at 2,000 kg | 107 | 5.03 | 150 | 2.52 | 17 | 2.08 | 10 | 3.01 | 29 | 1.53 | 89 | 6.03 | 103 | 2.52 |
| Hardness (N) at 5,000 kga | N/A | N/A | 45 | 5.52 | 15 | 3.21 | 35 | 4.04 | 120 | 1.56 | N/A | |||
aHigh hardness values and suitable release profiles were achieved for formulas #1, #2, and #7 at low 2,000 kg compression force; therefore, it was not necessary to produce tablets at higher compression forces. Higher compression force was applied to subsequent tablet formulas since they showed extremely low strength at lower compression force