Table I.
Solubility of Drug in Oils, Surfactants, and Cosurfactants
| Vehicle | Chemical composition | Solubility (mg/g), mean ± SD |
|---|---|---|
| Miglyol 810 | Caprylic/capric triglycerides | 1.16 ± 0.72 |
| Miglyol 812 | Caprylic/capric triglycerides | 2.50 ± 1.95 |
| Labrafac CC | Caprylic/capric triglycerides | 1.85 ± 0.46 |
| Labrafil 1944 CS | Oleoyl macrogolglycerides | 10.41 ± 0.95 |
| Lauroglycol 90 | Propylene glycol monolaurate | 76.51 ± 6.42 |
| Cremophor EL | Polyethoxylated castor oil | 106.26 ± 12.24 |
| Cremophor RH 40 | Polyoxyl 40 hydrogenated castor oil | 96.85 ± 1.12 |
| Transcutol P | Diethylene glycol monoethyl ether | 161.11 ± 12.18 |
| PEG 400 | Polyethylene glycol 400 | 105.94 ± 1.24 |
| Labrasol | Caprylocaproyl macrogolglycerides | 164.12 ± 1.56 |
| Tween 80 | Polysorbate 80/polyoxyethylene (20) sorbitan monooleate | 259.6 ± 22.64 |
| Labrafil 2125 CS | Linoleoyl macrogolglycerides | 12.14 ± 0.42 |