Table I.
Composition and Attributes of Wellbutrin SR 100 and 150 mg Tablets
| Ingredient | Original 100-mg strength (%) | Reformulated 100-mg strength (%) | 150-mg strength (%) |
|---|---|---|---|
| Bupropion hydrochloride | 37.0 | 30.8 | 37.5 |
| Hypromellose 2910, NF | 20.0 | 33.1 | 10.0 |
| Microcrystalline cellulose, NF | 36.0 | 29.0 | 49.6 |
| Cysteine hydrochloride, monohydrate, USP | 6.0 | 6.0 | 1.9 |
| Mg stearate, NF | 1.0 | 1.1 | 1.0 |
| Total core tablet weight (mg) | 270 | 325 | 400 |
| Core tablet diameter (mm) | 9.4 | 10 | 11 |
| Hypromellose 2910/cysteine hydrochloride ratio | 3.3 | 5.5 | 5.3 |
USP US Pharmacopeia, NF National Formulary