Table I.
Experimental Variables of Factorial Design with Their Coded Levels and Actual Values of Amoxicillin Gellan Beads, Results of Percent Yield, Percent Entrapment Efficiency, and Particle Size
| Batch | Gellan (X 1) | Amoxicillin (X 2) | Yield (%)a | Entrapment efficiency (%)a | Diameter (mm)a | |||
|---|---|---|---|---|---|---|---|---|
| Acidic | Alkaline | Acidic | Alkaline | Acidic | Alkaline | |||
| AM-1 | 1.5 (−1) | 700 (−1) | 53.87 ± 1.2 | 78.66 ± 1.1 | 35.78 ± 1.76 | 68.25 ± 1.77 | 0.70 ± 0.41 | 0.80 ± 0.4 |
| AM-2 | 1.5 (−1) | 800 (0) | 48.78 ± 1.1 | 76.25 ± 1.2 | 33.88 ± 2.1 | 66.25 ± 1 | 0.73 ± 0.5 | 0.83 ± 0.6 |
| AM-3 | 1.5 (−1) | 900 (+1) | 40.89 ± 1 | 70.45 ± 1.5 | 32.45 ± 2.13 | 60.45 ± 1.6 | 0.81 ± 0.4 | 0.84 ± 0.34 |
| AM-4 | 1.75 (0) | 700 (−1) | 45.34 ± 1.4 | 73.43 ± 1.2 | 42.08 ± 1.98 | 63.43 ± 1.88 | 0.82 ± 0.8 | 0.85 ± 0.78 |
| AM-5 | 1.75 (0) | 800 (0) | 57.98 ± 1.3 | 91.3 ± 0.97 | 39.45 ± 1.43 | 81.3 ± 1.33 | 0.83 ± 0.5 | 0.88 ± 0.6 |
| AM-6 | 1.75 (0) | 900 (+1) | 56.45 ± 0.9 | 89.27 ± 0.76 | 37.56 ± 1.89 | 79.27 ± 1.67 | 0.85 ± 0.5 | 0.89 ± 0.5 |
| AM-7 | 2.0 (+1) | 700 (−1) | 54.04 ± 1.8 | 79.74 ± 0.89 | 45.79 ± 2.1 | 69.74 ± 2 | 0.94 ± 0.3 | 0.98 ± 0.4 |
| AM-8 | 2.0 (+1) | 800 (0) | 65.34 ± 0.8 | 97.57 ± 0.5 | 40.01 ± 1.5 | 89.57 ± 1.54 | 0.99 ± 0.21 | 1.1 ± 0.4 |
| AM-9 | 2.0 (+1) | 900 (+1) | 63.45 ± 1.4 | 94.89 ± 0.9 | 38.2 ± 1.98 | 86.89 ± 1.78 | 1.1 ± 0.52 | 1.2 ± 0.5 |
aMean ± SD, n = 3