Table I.

Pharmacokinetic Parameters of Celecoxib in Human Volunteers (n = 6) After Administration of 200 mg as Single Oral Dose of Proniosomal Formulation and Celebrex® Capsules

PK parameter	Conventional capsule	Proniosomal capsule
C max (ng/ml)	705.17 ± 31.89	842.5 ± 34.72*
AUC0–48 (ng.h/ml)	6,761.58 ± 612.73	11,681.21 ± 523.90*
	7,210.58 ± 689.02	12,406.21 ± 469.11*a
T max (h)	2.5 ± 0.55	4 ± 0.00**
K a (h−1)	1.52 ± 0.17	0.73 ± 0.05*
K el (h−1)	0.051 ± 0.01	0.059 ± 0.002
t 1/2 (h)	13.33 ± 1.98	11.75 ± 0.55

Each value represents the mean ± standard division of six subjects

*P < 0.05 based on ANOVA, statistically significant difference between conventional and proniosomal capsules

**P < 0.05 based on Wilcoxon signed rank test, statistical significant difference between conventional and proniosomal capsules