Table I.

Effect of Time and Poloxamer 407 Concentration on Particle Size Reduction

Poloxamer 407 concentration (%)	Time (min; 10 cycles)	Size range at 20,000 rpm (nm)
		After 24 h	After 1 week
2	5	527–1,110	>1 µm
	10	135–770	>1 µm
	15	102–752	>1 µm
3	5	458–1,010	457–1,011
	10	45–403	46–406
	15	42–377	44–378
4	5	386–1,020	388–1,018
	10	49–531	51–534
	15	48–376	50–379